Connexins and steroidogenesis in mouse Leydig cells
نویسندگان
چکیده
منابع مشابه
Cox7a2 mediates steroidogenesis in TM3 mouse Leydig cells.
AIM To investigate the regulatory function of Cox7a2 on steroidogenesis and the mechanism involved in TM3 mouse Leydig cells. METHODS The cDNA of Cox7a2 was cloned from TM3 mouse Leydig cells. It was subcloned to pDsRed-Express-N1 and transfected back into TM3 mouse Leydig cells for Cox7a2 overexpression by transient gene transfection. Steroidogenesis affected by overexpressed Cox7a2 was stud...
متن کاملLeydig cells, thyroid hormones and steroidogenesis.
Leydig cells are the primary source of androgens in the mammalian testis. It is established that the luteinizing hormone (LH) produced by the anterior pituitary is required to maintain the structure and function of the Leydig cells in the postnatal testis. Until recent years, a role by the thyroid hormones on Leydig cells was not documented. It is evident now that thyroid hormones perform many ...
متن کاملCatecholamine stimulation of steroidogenesis in Leydig cells.
Although p-adrenergic control of another steroidogenic tissue, the ovary, has been established (Godkin et al., 1977; Jordan et al, 1978; Hunzicker-Dunn, 1980; Hunzicker-Dunn et al., 1979; Kliachko & Zor, 1981), there have been no reports that catecholamines can directly stimulate steroidogenesis in Leydig cells. During the course of our investigations on factors controlling Leydig activity in c...
متن کاملAqueous Extract of Nigella sativa Seeds Suppresses Testicular Steroidogenesis In Mice Leydig Cells, in vitro
Nigella sativa (black seed) is an important medicinal herb with folkloric use in wide range of diseases. It is well studied for its biological activities. However, there is limited information regarding its effect on the male reproductive system. This study describes the effect of the aqueous extract of N. sativa (NSE) on testicular steroidogenesis from mice Leydig cells in vitro . Mice tes...
متن کاملFibroblast Growth Factor 9 Activates Akt and MAPK Pathways to Stimulate Steroidogenesis in Mouse Leydig Cells
Fibroblast growth factor 9 (FGF9) is a multifunctional polypeptide belonging to the FGF family and has functions related to bone formation, lens-fiber differentiation, nerve development, gap-junction formation and sex determination. In a previous study, we demonstrated that FGF9 stimulates the production of testosterone in mouse Leydig cells. In the present study, we used both primary mouse Ley...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Physiology and Pharmacology
سال: 2013
ISSN: 0008-4212,1205-7541
DOI: 10.1139/cjpp-2012-0385